Key result
Fluctuating shear stress created by a typical handgrip protocol did not significantly alter the initial phase of brachial artery flow-mediated dilation compared to stable shear stress (P=0.196).
Why the study?
Does a fluctuating shear stress stimulus alter the brachial artery flow-mediated dilation response compared to a stable shear stimulus in healthy subjects?
Population
16 healthy subjects
Comparison
Fluctuating shear stress stimulus vs Stable shear stress stimulus
Design
Other
Authors
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Handgrip remains viable for brachial FMD testing; extends evidence that healthy endothelium transduces mean shear but leaves generalizability open.
Does a fluctuating shear stress stimulus alter the brachial artery flow-mediated dilation response compared to a stable shear stimulus in healthy subjects?
Absolute Event Rate: 5.63% vs 5.33%
p-value: p=0.196
The endothelium transduces mean shear stress regardless of fluctuations created by handgrip exercise, suggesting forearm exercise is a viable technique to investigate brachial artery FMD.
Pyke et al. (2008) studied Healthy (n=16). Fluctuating shear stress (handgrip exercise or cuff inflation) vs. Stable shear stress was evaluated on Initial phase of flow-mediated dilation (phase I) (p=0.196). Fluctuating shear stress created by a typical handgrip protocol did not significantly alter the initial phase of brachial artery flow-mediated dilation compared to stable shear stress (P=0.196).
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