Key result
Handgrip exercise assesses steady-state brachial FMD and yields distinct endothelial data compared to reactive hyperemia.
Why the study?
SS-FMD reflects conduit artery behavior during sustained exertional activity and provides distinct endothelial function information compared with reactive hyperemia-FMD, but methodological guidance was needed.
How can handgrip exercise be utilized to assess sustained shear stress flow-mediated dilation (SS-FMD) in the brachial artery?
How can handgrip exercise be utilized to assess sustained shear stress flow-mediated dilation (SS-FMD) in the brachial artery?
This methodological guide outlines the use of handgrip exercise to assess SS-FMD, offering distinct insights into endothelial function during sustained exertion.
May enable SS-FMD testing during sustained shear; leaves open outcome validation before clinical use.
This article provides the first methodological guide to utilize handgrip exercise for assessment of SS-FMD in the brachial artery in response to targeted steady state and incremental increases in shear stress. SS-FMD is a physiologically relevant response, reflecting conduit artery behavior during sustained exertional activity and can provide distinct information regarding endothelial function compared with reactive hyperemia-FMD.
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Lew et al. (2025) studied Endothelial function assessment. Handgrip exercise for SS-FMD assessment vs. Reactive hyperemia-FMD was evaluated. Handgrip exercise provides a methodological approach to assess steady-state flow-mediated dilation in the brachial artery, offering distinct endothelial function data compared to reactive hyperemia.
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