Key result
Renal transplant recipients had significantly higher arterial stiffness than healthy controls, with carotid augmentation index 7.4% higher (P=0.04) and pulse wave velocity 0.7 m/s higher (P=0.01).
Why the study?
Are arterial stiffness and wave reflections increased in renal transplant recipients compared to healthy controls?
Population
200 renal transplant recipients (RTR) and 44 healthy controls
Design
Cross-sectional
Authors
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May support vascular risk assessment in renal transplant recipients; leaves open whether GFR restoration or inflammation reduction improves stiffness.
Cross-Sectional (n=244)
Are arterial stiffness and wave reflections increased in renal transplant recipients compared to healthy controls?
Effect estimate: AI higher by 7.4 ± 3.6%; PWV higher by 0.7 ± 0.3 m/s
p-value: P=0.04 for AI, P=0.01 for PWV
Renal transplant recipients exhibit increased arterial stiffness and wave reflections compared to healthy controls, which is independently associated with incomplete restoration of GFR and subclinical inflammation.
Verbeke et al. (2007) conducted a cross-sectional in Renal transplant recipients (n=244). Renal transplant recipient status vs. Healthy controls was evaluated on Carotid augmentation index (AI) and carotid-femoral pulse wave velocity (PWV) (AI higher by 7.4 ± 3.6%; PWV higher by 0.7 ± 0.3 m/s, p=P=0.04 for AI, P=0.01 for PWV). Renal transplant recipients had significantly higher arterial stiffness than healthy controls, with carotid augmentation index 7.4% higher (P=0.04) and pulse wave velocity 0.7 m/s higher (P=0.01).
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