Key result
Reduced GFR is linked to increased large artery stiffness in renal transplant recipients.
Cross-Sectional (n=48)
p-value: p=< 0.05
Impaired renal allograft function is independently associated with increased arterial stiffness in renal transplant recipients, highlighting a link between kidney function and vascular health post-transplant.
Reduced GFR may warrant vascular monitoring in kidney transplant recipients; leaves open whether improving allograft function reduces stiffness.
It is important whether impairment of renal allograft function may deteriorate arterial stiffness in renal transplant recipients. In a cross-sectional study, arterial vascular characteristics were non-invasively determined in 48 patients with renal allograft using applanation tonometry and digital photoplethysmography. Mean age was 51 +/- 2 years (mean +/- SEM), and studies were performed 17 +/- 1 months after transplantation. The stage of chronic kidney disease was based on the glomerular filtration rate. We observed a significant association between the stage of chronic kidney disease and arterial stiffness of large arteries S1 and small arteries S2 in renal transplant recipients (each p < 0.05 by non-parametric Kruskal-Wallis test between groups). Multivariate linear regression analysis showed that male gender of patients with renal allograft (p < 0.01) reduced glomerular filtration rate (p = 0.01), and older age of kidney donor (p = 0.04) were independently associated with an increase of large artery stiffness S1. Furthermore, a significant association between the stage of chronic kidney disease and arterial vascular reactivity during reactive hyperemia was observed (p < 0.05 by non-parametric Kruskal-Wallis test between groups). It is concluded that impairment of renal allograft function is associated with an increased arterial stiffness in renal transplant recipients.
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Kneifel et al. (2006) conducted a cross-sectional in Renal transplant recipients (n=48). Impairment of renal allograft function (stage of chronic kidney disease) was evaluated on Arterial stiffness of large arteries S1 and small arteries S2 (p=< 0.05). Reduced glomerular filtration rate was independently associated with an increase in large artery stiffness in renal transplant recipients (p = 0.01).