Key result
Adjusted-dose warfarin reduced ischemic stroke or systemic embolism by 76% (95% CI 42-90; P<0.001) compared with aspirin plus low-dose warfarin in atrial fibrillation patients with stage 3 CKD.
Why the study?
Does adjusted-dose warfarin reduce ischemic stroke or systemic embolism in high-risk atrial fibrillation patients with stage 3 CKD?
Population
1,936 patients with atrial fibrillation participating in the Stroke Prevention in Atrial Fibrillation 3…
Comparison
Adjusted-dose warfarin vs Aspirin (325 mg) plus fixed, low-dose warfarin
Design
RCT, randomized trial
Authors
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Supports adjusted-dose warfarin for stroke prevention in AF with stage 3 CKD; extends randomized evidence to this high-risk subgroup.
RCT (n=1,936)
randomized
Does adjusted-dose warfarin reduce ischemic stroke or systemic embolism in high-risk atrial fibrillation patients with stage 3 CKD?
Effect estimate: 76% reduction (95% CI 42-90)
p-value: p=<0.001
Adjusted-dose warfarin is highly effective at reducing ischemic stroke and systemic embolism in high-risk atrial fibrillation patients with stage 3 CKD, without significantly increasing major hemorrhage.
Hart et al. (2011) conducted an RCT in Atrial fibrillation with stage 3 chronic kidney disease (n=1,936). Adjusted-dose warfarin vs. aspirin (325 mg) plus fixed, low-dose warfarin was evaluated on ischemic stroke or systemic embolism (76% reduction, 95% CI 42-90, p=<0.001). Adjusted-dose warfarin reduced ischemic stroke or systemic embolism by 76% (95% CI 42-90; P<0.001) compared with aspirin plus low-dose warfarin in atrial fibrillation patients with stage 3 CKD.
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