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This research aims to compare the susceptibility of beige mutant mice to cytomegalovirus infection compared to normal mice.

Increased susceptibility to cytomegalovirus infection in beige mutant mice.

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This research aims to compare the susceptibility of beige mutant mice to cytomegalovirus infection compared to normal mice.
Compared susceptibility of bg/bg and bg/+ C57BL/6J mice to murine cytomegalovirus (MCMV) infection.
Analyzed virus titers in liver, spleen, and kidney following infection.
Evaluated NK cell response and interferon type 1 levels in response to virus inoculation.
bg/bg mice show 33- to 43-fold higher virus titers in the liver, spleen, and kidney compared to bg/+ mice after infection.
NK cell response is lower in bg/bg mice, indicating their reduced ability to combat the virus.
Bone marrow chimeras with bg/bg marrow demonstrate increased susceptibility and decreased NK cell response compared to bg/+ chimeras.

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Randomized trial shows increased susceptibility to cytomegalovirus in beige mice, suggesting a role for NK cells in infection resistance.

Shellam et al. (1981) studied this question.

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