Key result
During a limb linkage rehabilitation task, stroke patients showed significantly lower effective connectivity in high-frequency intervals (p < 0.025) and increased influence of the motor and occipital cortices on the contralesional prefrontal cortex compared to healthy controls.
Why the study?
Stroke causes long-term disability, and the cortical activation and effective connectivity changes within functional brain networks during limb linkage rehabilitation training were unclear.
Does limb linkage rehabilitation training alter cortical activation and effective connectivity in stroke patients compared to healthy controls?
Comparison
Resting state vs upper and lower limb linkage motor rehabilitation task
Design
Functional near-infrared spectroscopy imaging study
Authors
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Should not yet change limb linkage protocols in stroke; hypothesis-generating for contralesional prefrontal targets.
Cross-Sectional (n=29)
No
Does limb linkage rehabilitation training alter cortical activation and effective connectivity in stroke patients compared to healthy controls?
p-value: p=<0.025
Huo et al. (2019) conducted a cross-sectional in Stroke (n=29). Limb linkage rehabilitation task vs. Healthy controls and resting state was evaluated on Effective connectivity (EC) in high-frequency intervals I and II (p=<0.025). During a limb linkage rehabilitation task, stroke patients showed significantly lower effective connectivity in high-frequency intervals (p < 0.025) and increased influence of the motor and occipital cortices on the contralesional prefrontal cortex compared to healthy controls.
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