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August 18, 2022Frontiers in NeuroscienceOpen Access

Increased cerebral cortex activation in stroke patients during electrical stimulation of cerebellar fastigial nucleus with functional near-infrared spectroscopy

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Authors

HMHaiyun MaYZYujia ZhaiZXZhen Xu

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Overview

Controlled study reveals increased prefrontal and motor cortex activation during fastigial nucleus stimulation in stroke patients, suggesting potential utility in neurorehabilitation.

Key Points

  • To evaluate resting-state functional connectivity alterations and measure cortical activation patterns induced by electrical stimulation of the cerebellar fastigial nucleus in stroke patients compared to healthy controls.
  • Enrolled 20 stroke patients and 20 healthy controls matched for age, gender, and BMI.
  • Administered 5 blocks of alternating resting state (30 s) and fastigial nucleus stimulation (30 s) while recording oxygenated hemoglobin concentrations via 39 fNIRS channels over the prefrontal, motor, and occipital cortices.
  • Computed resting-state functional connectivity using Pearson correlation coefficients and assessed stimulation-induced cortical activation using general linear models.
  • Stroke patients showed significantly lower resting-state functional connectivity between the right and left motor cortices (t = 4.65, p = 0.0007), right motor and left occipital cortices (t = 2.93, p = 0.04), and left motor and left occipital cortices (t = 2.81, p = 0.04).
  • During fastigial nucleus stimulation, stroke patients exhibited significant increases in oxygenated hemoglobin across 12 channels in bilateral prefrontal and motor cortices (FDR-corrected p < 0.05).
  • Healthy controls demonstrated significant stimulation-induced activation in only 1 channel located in the left prefrontal cortex (FDR-corrected p < 0.05).

Cite This Study

Ma et al. (2022) studied this question.

synapsesocial.com/papers/6a9bf8318680cd2c75850f99https://doi.org/10.3389/fnins.2022.895237
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