Key result
No. 7943 competitively inhibits the outward Na+/Ca2+ exchange current with an IC50 of approximately 0.32 microM, more potently than other membrane currents.
Population
Single cardiac ventricular cells of guinea-pig
Comparison
No. 7943 (0.1-50 microM) vs 3', 4'-dichlorobenzamil (DCB) at 3-30 microM
Design
Preclinical
Authors
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No. 7943 offers a selective NCX tool in guinea-pig myocytes; leaves open translation to human cardiac therapy.
No. 7943 potently and competitively inhibits the outward Na+/Ca2+ exchange current in guinea-pig ventricular cells.
Watano et al. (1996) studied this question. No. 7943 vs. 3', 4'-dichlorobenzamil (DCB) was evaluated on Na+/Ca2+ exchange current suppression. No. 7943 competitively inhibits the outward Na+/Ca2+ exchange current with an IC50 of approximately 0.32 microM, more potently than other membrane currents.
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