Key result
Various antiarrhythmic drugs and selective benzyloxyphenyl analogues inhibit the Na+/Ca2+ exchanger, acting either from the cytosolic side or from extracellular/intramembrane sites.
Population
Guinea-pig cardiac ventricular cells and transfected cells (CCL39 cells expressing NCX1)
Design
Review
Authors
Loading...
NCX inhibition by antiarrhythmics remains hypothesis-generating; should not yet influence clinical practice.
Pharmacological characterization reveals that several antiarrhythmic drugs and selective inhibitors block the Na+/Ca2+ exchanger via distinct binding sites, supporting the addition of NCX to the Sicilian Gambit classification of antiarrhythmic drugs.
Watanabe et al. (2006) reported a review. Na+/Ca2+ Exchanger Inhibitors was evaluated. Various antiarrhythmic drugs and selective benzyloxyphenyl analogues inhibit the Na+/Ca2+ exchanger, acting either from the cytosolic side or from extracellular/intramembrane sites.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: