Why the study?
Does chronic amiodarone administration affect Na+/Ca2+ exchange current and NCX1 mRNA levels in guinea pig ventricular myocytes?
Population
Guinea pig ventricular myocytes (from guinea pigs)
Comparison
Amiodarone 80 mg/kg per day intraperitoneally… vs Vehicle intraperitoneally for 1 or 4 weeks
Design
Preclinical
Follow-up
1 or 4 weeks
Authors
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Amiodarone prolongs APD without altering INCX or NCX1 in guinea pigs; leaves open NCX contribution to its clinical effects.
Does chronic amiodarone administration affect Na+/Ca2+ exchange current and NCX1 mRNA levels in guinea pig ventricular myocytes?
Chronic amiodarone administration prolongs action potential duration but does not alter Na+/Ca2+ exchange current or NCX1 mRNA expression in guinea pig ventricular myocytes.
Watanabe et al. (2002) studied this question.
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