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September 1, 2000British Journal of PharmacologyOpen Access

Inhibitory effect of amiodarone on Na+/Ca2+ exchange current in guinea‐pig cardiac myocytes

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Key result

Amiodarone suppressed the Na+/Ca2+ exchange current in guinea-pig ventricular myocytes in a concentration-dependent manner with an IC50 of 3.3 microM.

Why the study?

Does amiodarone inhibit Na+/Ca2+ exchange current in guinea-pig ventricular myocytes?

Population

Single guinea-pig ventricular myocytes

Design

Preclinical

Authors

YWYasuhide WatanabeFukushima Medical UniversityJKJunko KimuraGunma Astronomical Observatory

Discussion

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Implication

May contribute to amiodarone's effects in guinea-pig myocytes; hypothesis-generating for human translation.

Structured PICO

Does amiodarone inhibit Na+/Ca2+ exchange current in guinea-pig ventricular myocytes?

P
Population
Single guinea-pig ventricular myocytes
I
Intervention
Amiodarone (external application)
O
Outcome
Na+/Ca2+ exchange current (I(NCX))surrogate

Main Result

Effect estimate: IC50 3.3 microM

Amiodarone inhibits the Na+/Ca2+ exchanger from the cytoplasmic side, which may contribute to its cardioprotective action.

Cite This Study

Watanabe et al. (2000) studied this question. Amiodarone was evaluated on Na+/Ca2+ exchange current (I(NCX)) (IC50 3.3 microM). Amiodarone suppressed the Na+/Ca2+ exchange current in guinea-pig ventricular myocytes in a concentration-dependent manner with an IC50 of 3.3 microM.

synapsesocial.com/papers/6a557f22cae1d55e053ea901https://doi.org/10.1038/sj.bjp.0703527
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of the chronic and acute effects of amiodarone on the calcium and potassium currents in rabbit isolated cardiac myocytes1996 · 74 citations
  2. 2Effects of class III antiarrhythmic drugs on the Na+‐activated K+ channels in guinea‐pig ventricular cells1996 · 32 citations
  3. 3Inactivation of outward Na(+)‐Ca2+ exchange current in guinea‐pig ventricular myocytes.1994 · 87 citations
  4. 4Suppression of time-dependent outward current in guinea pig ventricular myocytes. Actions of quinidine and amiodarone.1991 · 169 citations
  5. 5A Novel Isothiourea Derivative Selectively Inhibits the Reverse Mode of Na+/Ca2+ Exchange in Cells Expressing NCX11996 · 505 citations