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June 1, 2002British Journal of PharmacologyOpen Access

Inhibitory effect of aprindine on Na+/Ca2+ exchange current in guinea‐pig cardiac ventricular myocytes

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Why the study?

Does aprindine inhibit Na+/Ca2+ exchange current in cardiac ventricular myocytes?

Population

Guinea-pig single cardiac ventricular myocytes and CCL39 fibroblasts expressing a dog cardiac Na+/Ca2+…

Design

Preclinical

Authors

YWYasuhide WatanabeFukushima Medical UniversityTITakahiro IwamotoOkayama UniversityMSMunekazu ShigekawaElectrophysiology

Discussion

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Implication

Aprindine may affect NCX-mediated calcium handling in myocytes; leaves open its contribution to antiarrhythmic effects in vivo.

Structured PICO

Does aprindine inhibit Na+/Ca2+ exchange current in cardiac ventricular myocytes?

P
Population
Guinea-pig single cardiac ventricular myocytes and CCL39 fibroblasts expressing a dog cardiac Na+/Ca2+ exchanger (NCX1)
I
Intervention
Aprindine (external application)
O
Outcome
Na+/Ca2+ exchange current (I(NCX))surrogate

Aprindine modestly inhibits the Na+/Ca2+ exchange current at therapeutic concentrations, likely acting at an external or intra-membranous site.

Cite This Study

Watanabe et al. (2002) studied this question.

synapsesocial.com/papers/6a82f48dc009eb9b7eefdb39https://doi.org/10.1038/sj.bjp.0704721
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibitory effect of amiodarone on Na<sup>+</sup>/Ca<sup>2+</sup> exchange current in guinea‐pig cardiac myocytes2000 · 67 citations
  2. 2Physiological functions of the regulatory domains of the cardiac Na<sup>+</sup>/Ca<sup>2+</sup>exchanger NCX12000 · 35 citations
  3. 3Profiles of Aprindine, Cibenzoline, Pilsicainide and Pirmenol in the Framework of the Sicilian Gambit1999 · 56 citations
  4. 4Sodium/Calcium Exchange: Its Physiological Implications1999 · 1,749 citations
  5. 5Na+-Ca2+ Exchanger: Physiology and Pharmacology.1997 · 98 citations