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January 1, 1983Journal of Cardiovascular Pharmacology

Aprindine Inhibits Calmodulin-Stimulated Phosphodiesterase and Ca-ATPase Activities

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Authors

SLSteven N. LevineLouisiana State University Health Sciences Center ShreveportBHBecky HollierLouisiana State University in Shreveport

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Implication

Hypothesis-generating for aprindine’s biochemical mechanism; leaves open relevance to human arrhythmia therapy.

Key Points

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Cite This Study

Levine et al. (1983) studied this question.

synapsesocial.com/papers/6a90186f17e522ae792b049fhttps://doi.org/10.1097/00005344-198301000-00023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Frequency- and Voltage-Dependent Effects of Aprindine on the Upstroke Velocity of Action Potential in Guinea Pig Ventricular Muscles1987 · 18 citations
  2. 2Inhibitory effect of aprindine on Na<sup>+</sup>/Ca<sup>2+</sup> exchange current in guinea‐pig cardiac ventricular myocytes2002 · 17 citations
  3. 3Inhibitory effects of aprindine on the delayed rectifier K<sup>+</sup> current and the muscarinic acetylcholine receptor‐operated K<sup>+</sup> current in guinea‐pig atrial cells1999 · 27 citations
  4. 4Pharmacokinetics and pharmacodynamics after administration of a single oral dose of aprindine hydrochloride.1985 · 1 citations
  5. 5Effects of Aprindine on Ischemia/Reperfusion-Induced Cardiac Contractile Dysfunction of Perfused Rat Heart1996 · 6 citations