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January 1, 1996The Japanese Journal of PharmacologyOpen Access

Effects of Aprindine on Ischemia/Reperfusion-Induced Cardiac Contractile Dysfunction of Perfused Rat Heart

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Why the study?

Does aprindine improve ischemia/reperfusion-induced cardiac contractile dysfunction and metabolic derangement in isolated perfused rat hearts?

Population

Isolated rat hearts subjected to 35-min global ischemia followed by 60-min reperfusion

Comparison

Aprindine administered for the last 3 min of… vs Without aprindine treatment (control)

Design

Preclinical

Follow-up

60-min reperfusion

Authors

TKToru KamiyamaChugai Pharma (United States)KTK TanonakaTokyo University of Pharmacy and Life SciencesJHJyun-ichi HayashiSapporo Medical University

Discussion

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Implication

Aprindine shows potential cardioprotection in rat ischemia/reperfusion; leaves open translation to human clinical use.

Structured PICO

Does aprindine improve ischemia/reperfusion-induced cardiac contractile dysfunction and metabolic derangement in isolated perfused rat hearts?

P
Population
Isolated rat hearts subjected to 35-min global ischemia followed by 60-min reperfusion
I
Intervention
Aprindine (10, 30, 70, or 100 microM) administered for the last 3 min of pre-ischemia
C
Comparator
Without aprindine treatment (control)
O
Outcome
Cardiac contractile recovery (left ventricular developed pressure [LVDP] and left ventricular end-diastolic pressure [LVEDP]) and metabolic derangement (myocardial ion content, ATP metabolites, creatine kinase release)surrogate

Aprindine at lower concentrations (10-30 microM) exerts cardioprotective effects against ischemia/reperfusion injury in isolated rat hearts, likely by suppressing transmembrane flux and preventing myocardial sodium accumulation.

Cite This Study

Kamiyama et al. (1996) studied this question.

synapsesocial.com/papers/6a826bdb70df46ce3ea21523https://doi.org/10.1254/jjp.70.227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aprindine Inhibits Calmodulin-Stimulated Phosphodiesterase and Ca-ATPase Activities1983 · 8 citations
  2. 2R56865, a Potent New Antiarrhythmic Agent, Effective During Ischemia and Reperfusion in the Rat Heart1990 · 28 citations
  3. 3Relationship between adenine nucleotide metabolism and irreversible ischemic tissue damage in isolated perfused rat heart.1979 · 176 citations
  4. 4Myocardial protection by R 56865: a new principle based on prevention of ion channel pathology1991 · 51 citations
  5. 523Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion1990 · 144 citations