Key result
Bepridil, tetrodotoxin, verapamil, and diltiazem reduced the incidence of reperfusion-induced arrhythmias in isolated rat hearts, whereas nifedipine and nitrendipine did not.
Why the study?
Does bepridil compared to other ion channel blockers reduce reperfusion-induced arrhythmias in isolated perfused rat hearts?
Population
Isolated perfused rat heart model
Comparison
Bepridil (1-4 microM) vs Tetrodotoxin, verapamil, diltiazem, nifedipine…
Design
Preclinical
Authors
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No immediate clinical implications for reperfusion arrhythmias; leaves open bradycardia's protective role for human studies.
Does bepridil compared to other ion channel blockers reduce reperfusion-induced arrhythmias in isolated perfused rat hearts?
Bepridil and other heart-rate lowering calcium antagonists protect against reperfusion-induced arrhythmias in isolated rat hearts, suggesting bradycardia plays a key antiarrhythmic role.
Winslow et al. (1983) studied Reperfusion-induced arrhythmias. Bepridil vs. Tetrodotoxin, verapamil, diltiazem, nifedipine, and nitrendipine was evaluated on Incidence of reperfusion-induced arrhythmias (RA). Bepridil, tetrodotoxin, verapamil, and diltiazem reduced the incidence of reperfusion-induced arrhythmias in isolated rat hearts, whereas nifedipine and nitrendipine did not.
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