Population
Closed chest anaesthetized dogs
Comparison
Bepridil and its quaternary derivative CERM 11888 vs Verapamil and diltiazem (0.2 mg kg-1 i.v.)
Design
Preclinical
Authors
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Animal data indicate distinct calcium channel blocker profiles; leaves open translation to human arrhythmia management.
Bepridil exhibits a broader electrophysiological spectrum than verapamil and diltiazem, affecting atrial and ventricular tissues in addition to the SA and AV nodes.
Leboeuf et al. (1989) studied this question.
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