Why the study?
Does bepridil affect intracellular calcium concentration and contraction differently than D600 in cultured rat ventricular myocytes?
Population
Cultured neonatal rat ventricular cells
Comparison
Bepridil (1-30 microM) vs D600 (methoxyverapamil) (1-30 microM)
Design
Preclinical
Authors
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Bepridil's Ca2+ effects in rat myocytes should not alter clinical practice; leaves open translation to human myocardium.
Does bepridil affect intracellular calcium concentration and contraction differently than D600 in cultured rat ventricular myocytes?
Bepridil demonstrates a unique profile among calcium channel blockers by offsetting its negative inotropic effect through increased calcium sensitivity of contractile proteins.
Ozaki et al. (1999) studied this question.
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