Key result
Bepridil produced a dose-dependent depression and complete blockade of Ca2+-dependent action potentials in isolated dog coronary arteries at 1 X 10(-5) M.
Bepridil acts as a calcium channel blocker in vascular smooth muscle, explaining its vasodilatory and antianginal properties.
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Supports bepridil's calcium channel blockade in canine vessels; leaves open translation to human antianginal therapy.
Harder et al. (1981) studied this question. Bepridil (CERM-1978) was evaluated on Ca2+-dependent overshooting action potentials. Bepridil produced a dose-dependent depression and complete blockade of Ca2+-dependent action potentials in isolated dog coronary arteries at 1 X 10(-5) M.
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