What is the clinical evidence from this study?

Study design: Other. Intervention: Bepridil (CERM-1978) vs. Verapamil. Primary outcome: Contractile responses to high K+ and norepinephrine.

What does this research mean for the field?

Bepridil depresses vascular smooth muscle contractions induced by potassium and norepinephrine with potency comparable to verapamil, primarily by inhibiting extracellular calcium influx. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To assess and compare the inhibitory effects of bepridil and verapamil on contractile responses in vascular smooth muscle under diverse stimulation conditions.

September 19, 2008Blood Vessels

Bepridil (CERM-1978) and Verapamil Depression of Contractions of Rabbit Aortic Rings

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Key result

Bepridil depresses vascular smooth muscle contraction similarly to verapamil by inhibiting calcium influx.

Why the study?

The effects of bepridil, a new antianginal agent, on vascular smooth muscle contraction compared to verapamil were investigated.

Population

Isolated rings of rabbit ascending aorta about 1 mm wide

Comparison

Bepridil (10(-5)-10(-6) M) vs verapamil (10(-5)-10(-6) M)

Design

Preclinical experimental study

Follow-up

20 min after addition

Authors

SMSuzanne MrasUniversity of Virginia NSNick SperelakisUniversity of Virginia

Discussion

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Implication

Bepridil inhibits aortic contractions in vitro similarly to verapamil; leaves open its clinical role in angina.

Key Points

To assess and compare the inhibitory effects of bepridil and verapamil on contractile responses in vascular smooth muscle under diverse stimulation conditions.
Isolated 1-mm rings of rabbit ascending aorta and evaluated contractile responses 20 minutes after adding bepridil (10⁻⁵–10⁻⁶ M) or verapamil (10⁻⁵–10⁻⁶ M).
Stimulated tissues using norepinephrine (10⁻⁶ M), elevated potassium (30 mM), or strong electrical field stimulation in physiological and calcium-free EGTA-containing media.
Bepridil and verapamil depressed contractile responses to high potassium and norepinephrine with near-identical potency, whereas responses to electrical field stimulation remained unaffected.
Neither drug altered norepinephrine-induced contractions in calcium-free EGTA solutions, but bepridil markedly depressed contractions triggered by norepinephrine in depolarized tissues.

Structured PICO

Population

Isolated rings (about 1 mm wide) of rabbit ascending aorta

Intervention

Bepridil (CERM-1978) (10(-5)-10(-6) M)

Comparator

Verapamil (10(-5)-10(-6) M)

Outcome

Contractile responses to norepinephrine (NE), increased extracellular potassium ion concentration, or electrical stimulationsurrogate

Bepridil acts as a calcium channel blocker in vascular smooth muscle, similarly to verapamil, by decreasing extracellular calcium influx.

Cite This Study

Mras et al. (2008) studied this question. Bepridil (CERM-1978) vs. Verapamil was evaluated on Contractile responses to high K+ and norepinephrine. Bepridil, like verapamil, depressed the contractile responses of isolated rabbit aortic rings to high potassium and norepinephrine, suggesting it inhibits contractions by decreasing calcium influx.

synapsesocial.com/papers/6ab60fb64343ed835e7c6fda https://doi.org/10.1159/000158354

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Bepridil (CERM-1978) and Verapamil Depression of Contractions of Rabbit Aortic Rings

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Bepridil (CERM-1978) and Verapamil Depression of Contractions of Rabbit Aortic Rings

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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