Key result
Mesudipine outperforms other calcium antagonists in suppressing arterial and venous vascular smooth muscle contractions.
Why the study?
The comparative effects of several Ca++-antagonistic and vasodilating drugs on arterial and venous smooth muscle contractions were investigated to determine their relative potencies.
Population
Isolated rings of rabbit aorta and guinea pig inferior vena cava
Comparison
Mesudipine, verapamil, diltiazem, nifedipine, and bepridil effects compared
Design
In vitro pharmacological study on isolated vascular smooth muscle preparations
Authors
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These isolated vessel findings should not guide clinical vasodilator selection; leaves open differential arterial-venous Ca++ antagonism for further study.
Mesudipine demonstrates potent calcium-antagonistic and vasodilating properties in isolated arterial and venous smooth muscle preparations.
Sperelakis et al. (2008) studied this question. Mesudipine and other slow channel blockers was evaluated on Depression of K+-induced and NE-induced contractures. Mesudipine was the most potent inhibitor of K+-induced contractions in both arterial and venous vascular smooth muscle compared to other calcium antagonists.
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