Why the study?
Do calcium antagonistic drugs depress the action potentials and automaticity in the isolated rabbit sinoatrial node?
Population
Isolated spontaneously-contracting sinoatrial (SA)-node of the rabbit
Comparison
Calcium antagonistic drugs at various… vs Baseline/control and comparison between…
Design
Preclinical
Authors
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May explain bradycardia risk with calcium antagonists; leaves open translation from rabbit SA-node preparations.
Do calcium antagonistic drugs depress the action potentials and automaticity in the isolated rabbit sinoatrial node?
Calcium channel blockers dose-dependently depress action potentials and automaticity in the rabbit sinoatrial node, with varying potencies.
Molyvdas et al. (1986) studied this question.
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