Why the study?
Does FR-34235 affect action potentials and contractions in isolated guinea pig papillary muscles and Purkinje fibers compared to nifedipine and verapamil?
Population
Isolated guinea pig papillary muscles and Purkinje fibers
Comparison
FR-34235 (a new dihydropyridine analog) vs Nifedipine and verapamil
Design
Preclinical
Authors
Loading...
Preclinical frequency-dependent calcium antagonism by FR-34235 in guinea pig tissue; leaves open translation to human electrophysiology or therapy.
Does FR-34235 affect action potentials and contractions in isolated guinea pig papillary muscles and Purkinje fibers compared to nifedipine and verapamil?
FR-34235 demonstrates calcium antagonist properties by blocking slow action potentials and contractions in guinea pig cardiac tissues in a frequency-dependent manner.
Molyvdas et al. (1986) studied this question.