Population
Guinea pig papillary muscles
Comparison
Mesudipine (10^-8 to 10^-5 M) vs Verapamil (5 x 10^-6 M) and nifedipine (10^-7 M)
Design
Preclinical
Authors
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Preclinical data on mesudipine leave open its development as a calcium channel blocker; human trials needed before any clinical consideration.
Mesudipine is a potent calcium slow-channel blocker with similar electrophysiological effects to nifedipine in preclinical models.
Molyvdas et al. (1983) studied this question.
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