May 1, 1989The Journal of PhysiologyOpen Access

Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric artery depends on voltage.

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Population

rabbit mesenteric artery

Comparison

nisoldipine and membrane depolarization vs baseline conditions or different membrane…

Design

Preclinical

Authors

MNMark T. NelsonUniversity of Vermont JWJennings F. WorleyVertex Pharmaceuticals (United States)

Discussion

Member takes

Implication

Nisoldipine shows state-dependent vascular calcium-channel inhibition; leaves open translation to human therapy.

Structured PICO

Population

rabbit mesenteric artery

Intervention

nisoldipine (with or without Bay K 8644) and membrane depolarization

Comparator

baseline conditions or different membrane potentials

Outcome

single calcium channel currents and arterial contractionsurrogate

Nisoldipine binds with higher affinity to the inactivated state than to the resting state of calcium channels in the rabbit mesenteric artery, with inhibition increasing upon membrane depolarization.

Cite This Study

Nelson et al. (1989) studied this question.

synapsesocial.com/papers/6a8387c7b397c5df40cd7d8b https://doi.org/10.1113/jphysiol.1989.sp017604

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Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric artery depends on voltage.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric artery depends on voltage.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider