Population
Rabbit spontaneously beating and voltage-clamped sinoatrial (SA) node cells
Comparison
CD-349 at concentrations of 10 to 10 M vs Nifedipine, diltiazem, and verapamil
Design
Preclinical
Authors
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Alerts to potential sinus node effects in translation; leaves open therapeutic selectivity pending human data.
In a preclinical rabbit model, the novel calcium antagonist CD-349 demonstrated greater potency in decreasing sinoatrial node pacemaker activity compared to nifedipine, diltiazem, and verapamil.
Satoh et al. (1993) studied this question.
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