Key result
In isolated rabbit tissues, clentiazem and nimodipine were selective for relaxing potassium-induced contractions in the basilar artery compared to the mesenteric artery.
Population
Isolated rabbit right atria and vascular smooth muscle
Comparison
Clentiazem vs Diltiazem, verapamil, nifedipine, and nimodipine
Design
Preclinical
Authors
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Hypothesis-generating for cerebrovascular selectivity; leaves open translation to human vasospasm or migraine therapy.
In isolated rabbit tissues, clentiazem showed selectivity for relaxing basilar arteries during potassium-induced contractions, distinguishing its pharmacological profile from diltiazem.
Mecca et al. (1992) studied this question. Clentiazem vs. Diltiazem, verapamil, nifedipine, and nimodipine was evaluated on Relative cardiodepressive potencies and relaxation of potassium- or norepinephrine-induced contractions. In isolated rabbit tissues, clentiazem and nimodipine were selective for relaxing potassium-induced contractions in the basilar artery compared to the mesenteric artery.
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