Why the study?
Does polypeptide vasoconstrictor activity correlate with mean arterial pressure and serum potassium in patients with renal, malignant, and primary hypertension?
Population
65 subjects, comprising 45 patients with renal, malignant, and primary hypertension, and 20 normal subjects.
Design
Cross-sectional
Authors
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Supports RAAS activation across hypertension via potassium link; leaves open causality and therapeutic implications.
Does polypeptide vasoconstrictor activity correlate with mean arterial pressure and serum potassium in patients with renal, malignant, and primary hypertension?
Elevated plasma vasoconstrictor activity in hypertensive patients inversely correlates with serum potassium, suggesting activation of the renin-angiotensin-aldosterone mechanism in various hypertensive states.
Fitz et al. (1964) studied this question.
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