Key result
Sustained cardiomyocyte PHD loss triggers dilated cardiomyopathy, phenocopying chronic ischemic cardiomyopathy.
Why the study?
Does sustained loss of PHD activity and subsequent hypoxia-inducible factor activation in cardiomyocytes lead to changes resembling ischemic cardiomyopathy?
Does sustained loss of PHD activity and subsequent hypoxia-inducible factor activation in cardiomyocytes lead to changes resembling ischemic cardiomyopathy?
Sustained loss of PHD activity and subsequent HIF activation in cardiomyocytes are sufficient to cause dilated cardiomyopathy, phenocopying chronic ischemic cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Should not yet inform clinical practice; extends preclinical evidence linking PHD-HIF pathway to ischemic cardiomyopathy phenotypes.
BACKGROUND: Ischemic cardiomyopathy is the major cause of heart failure and a significant cause of morbidity and mortality. The degree of left ventricular dysfunction in this setting is often out of proportion to the amount of overtly infarcted tissue, and how decreased delivery of oxygen and nutrients leads to impaired contractility remains incompletely understood. The Prolyl Hydroxylase Domain-Containing Protein (PHD) prolyl hydroxylases are oxygen-sensitive enzymes that transduce changes in oxygen availability into changes in the stability of the hypoxia-inducible factor transcription factor, a master regulator of genes that promote survival in a low-oxygen environment. METHODS AND RESULTS: We found that cardiac-specific PHD inactivation causes ultrastructural, histological, and functional changes reminiscent of ischemic cardiomyopathy over time. Moreover, long-term expression of a stabilized hypoxia-inducible factor alpha variant in cardiomyocytes also led to dilated cardiomyopathy. CONCLUSIONS: Sustained loss of PHD activity and subsequent hypoxia-inducible factor activation, as would occur in the setting of chronic ischemia, are sufficient to account for many of the changes in the hearts of individuals with chronic coronary artery disease.
No takes yet. Share an insight, caveat, or question.
Moslehi et al. (2010) studied Ischemic cardiomyopathy. Cardiac-specific PHD inactivation (PHD2 and PHD3 loss) and HIF activation vs. Littermate controls (PHD-intact mice) was evaluated on Cardiac structural, histological, and functional changes (including left ventricular dysfunction and dilated cardiomyopathy). Sustained loss of PHD activity and subsequent hypoxia-inducible factor activation in cardiomyocytes is sufficient to induce dilated cardiomyopathy, phenocopying chronic ischemic cardiomyopathy.
Synapse has enriched 10 related papers. Consider them for comparative context: