Key result
In perfused rat hearts, endocardial levels of diastolic and systolic [Ca2+]i were higher than epicardial levels and rose to a greater degree during low-flow ischemia.
In perfused rat hearts, the endocardium exhibits higher baseline intracellular calcium levels and a greater increase during low-flow ischemia compared to the epicardium, indicating higher susceptibility to ischemia.
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Suggests endocardial ischemic vulnerability in rats; leaves open relevance of transmural calcium gradients to human MI.
Figueredo et al. (1993) studied Myocardial ischemia. Endocardial measurement vs. Epicardial measurement was evaluated on Intracellular free calcium ([Ca2+]i) levels. In perfused rat hearts, endocardial levels of diastolic and systolic [Ca2+]i were higher than epicardial levels and rose to a greater degree during low-flow ischemia.
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