December 1, 1998The Journal of Urology
Mechanisms of Ischemia-Induced Cavernosal Smooth Muscle Relaxation Impairment in a Rabbit Model of Vasculogenic Erectile Dysfunction
Key result
Hypercholesterolemia and chronic cavernosal ischemia significantly reduced endothelium-dependent relaxation of cavernosal tissue to acetylcholine compared with the control group.
Why the study?
Does hypercholesterolemia and chronic cavernosal ischemia impair cavernosal smooth muscle relaxation in a rabbit model?
Population
New Zealand White rabbits
Comparison
Hypercholesterolemia or chronic cavernosal… vs Control group fed a regular diet
Design
Preclinical
Follow-up
16 weeks
Authors
Discussion
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Implication
Suggests vascular ED mechanisms in rabbits; hypothesis-generating and should not yet change practice.
Structured PICO
Does hypercholesterolemia and chronic cavernosal ischemia impair cavernosal smooth muscle relaxation in a rabbit model?
P
Population
37 New Zealand White rabbits divided into control, hypercholesterolemia, and chronic cavernosal ischemia groups followed for 16 weeks.
I
Intervention
Hypercholesterolemia (0.5% cholesterol diet) or chronic cavernosal ischemia (balloon de-endothelialization of iliac arteries + 0.5% cholesterol diet) for 16 weeks, with in vitro tissue treatment using indomethacin and L-arginine
C
Comparator
Control group fed a regular diet
O
Outcome
Iliac arterial blood flow, reactivity of cavernosal tissue (endothelium-dependent and neurogenic relaxation), cavernosal NOS activity, and cavernosal tissue synthesis of constrictor eicosanoidssurrogate
Hypercholesterolemia and atherosclerosis-induced chronic cavernosal arterial insufficiency adversely affect smooth muscle relaxation mechanisms in cavernosal tissue by disrupting NO formation and increasing constrictor eicosanoids.
Cite This Study
Azadzoi et al. (1998) studied Vasculogenic erectile dysfunction (n=37). Hypercholesterolemia and chronic cavernosal ischemia vs. Control (regular diet) was evaluated on Endothelium-dependent relaxation of cavernosal tissue to acetylcholine. Hypercholesterolemia and chronic cavernosal ischemia significantly reduced endothelium-dependent relaxation of cavernosal tissue to acetylcholine compared with the control group.