December 1, 1998The Journal of Urology
Mechanisms of Ischemia-Induced Cavernosal Smooth Muscle Relaxation Impairment in a Rabbit Model of Vasculogenic Erectile Dysfunction
Key result
Hypercholesterolemia and chronic cavernosal ischemia significantly impaired endothelium-dependent and neurogenic relaxation of cavernosal tissue in a rabbit model.
Population
New Zealand White rabbits (n=37 total: 10 control, 13 hypercholesterolemia, 14 chronic cavernosal ischemia)
Comparison
Hypercholesterolemia and chronic cavernosal… vs Control group fed a regular diet
Design
Preclinical
Follow-up
16 weeks
Authors
Discussion
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Implication
Should not yet change erectile dysfunction practice; hypothesis-generating for hypercholesterolemia effects on cavernosal nitric oxide pathways.
Structured PICO
P
Population
37 New Zealand White rabbits divided into control, hypercholesterolemia, and chronic cavernosal ischemia groups to study erectile dysfunction mechanisms over 16 weeks.
I
Intervention
Hypercholesterolemia (0.5% cholesterol diet) and chronic cavernosal ischemia (balloon deendothelialization of iliac arteries + 0.5% cholesterol diet) for 16 weeks, with ex vivo tissue treatment using indomethacin and L-arginine
C
Comparator
Control group fed a regular diet
O
Outcome
Iliac arterial blood flow, reactivity of cavernosal tissue, cavernosal NOS activity, and cavernosal tissue synthesis of constrictor eicosanoidssurrogate
Hypercholesterolemia and atherosclerosis-induced chronic cavernosal arterial insufficiency impair cavernosal smooth muscle relaxation mechanisms via disruption of NO formation and increased constrictor eicosanoids.
Cite This Study
Azadzoi et al. (1998) studied Vasculogenic erectile dysfunction (n=37). Hypercholesterolemia and chronic cavernosal ischemia vs. Regular diet (control) was evaluated on Endothelium-dependent and neurogenic relaxation of cavernosal tissue. Hypercholesterolemia and chronic cavernosal ischemia significantly impaired endothelium-dependent and neurogenic relaxation of cavernosal tissue in a rabbit model.