Long-term Efficacy of a New Formulation of Prostaglandin E1 as Treatment for Erectile Failure

PURPOSE: We determined the long-term efficacy of intracavernous injection of a new formulation of prostaglandin E1 (Caverject) as treatment for erectile failure. MATERIALS AND METHODS: A prospective study was done at a university affiliated Veterans Affairs medical center. Subjects with erectile failure received injections of prostaglandin E1 at the office and self-administered injections at home for up to 18 months. RESULTS: Of 16 patients who performed home injections 15 completed 6 months and 10 completed 18 months of therapy. Patient and spousal satisfaction with intercourse was 90% for months 1 to 6, and patient satisfaction was 95% for months 7 to 18. CONCLUSIONS: Prostaglandin E1 was highly effective at producing penile rigidity and an erection with satisfactory vaginal intercourse.