Key result
Cultured myofibroblasts from myocardial infarction scar tissue express endothelin-1 and its receptors de novo, upregulating type I collagen synthesis which is blocked by bosentan.
Cardiac myofibroblasts from myocardial infarction scar tissue express and generate endothelin-1 de novo, which upregulates type I collagen expression and may contribute to tissue repair in an autocrine/paracrine manner.
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May implicate ET-1 in post-MI fibrosis; leaves open whether bosentan alters in vivo scar remodeling.
Laxmansa C. Katwa (2003) studied Myocardial infarction. Endothelin-1 and Bosentan was evaluated on Expression of ET precursor gene, ECE-1, ETA/ETB receptors, and type I collagen synthesis. Cultured myofibroblasts from myocardial infarction scar tissue express endothelin-1 and its receptors de novo, upregulating type I collagen synthesis which is blocked by bosentan.
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