Key result
In mice with surgically induced acute myocardial infarction, ventricular rupture incidence varied by strain (3% to 59%) and was lower in females than males (23% vs. 59%, P<0.05).
Population
Male and female mice of three strains with surgically induced acute myocardial infarction
Design
Preclinical
Follow-up
up to 6 days
Authors
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Strain- and sex-specific rupture risks in murine MI models require cautious interpretation; leaves open translation to human risk stratification.
p-value: p=<0.05
Post-infarct left ventricular wall rupture in mice is strain- and gender-dependent, occurring within a narrow 2-6 day window due to reduced myocardial tensile strength.
Gao et al. (2004) studied Acute myocardial infarction. Surgically induced acute myocardial infarction was evaluated on Incidence of ventricular rupture (p=<0.05). In mice with surgically induced acute myocardial infarction, ventricular rupture incidence varied by strain (3% to 59%) and was lower in females than males (23% vs. 59%, P<0.05).
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