Key result
Calcium entry mediates most of the calcium current inactivation in frog atrial fibers, with relative inactivation linearly related to the amount of divalent cations carried into the cell.
This preclinical study demonstrates that calcium entry mediates the majority of calcium current inactivation in frog atrial fibers.
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No clinical implications yet; leaves open whether Ca entry drives I_Ca inactivation in mammalian myocytes.
Mentrard et al. (1984) studied this question. Ion substitutions and voltage-clamp was evaluated on Ca current inactivation. Calcium entry mediates most of the calcium current inactivation in frog atrial fibers, with relative inactivation linearly related to the amount of divalent cations carried into the cell.
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