Key result
Calcium entry mediates most of the calcium current inactivation in frog atrial fibers, with relative inactivation linearly related to the amount of divalent cations carried into the cell.
Population
Frog atrial muscle fibers (Cs-loaded)
Comparison
Voltage-clamp with various ionic substitutions… vs Normal calcium conditions
Design
Preclinical
Authors
Loading...
No clinical implications yet; leaves open whether Ca entry drives I_Ca inactivation in mammalian myocytes.
This preclinical study demonstrates that calcium entry mediates the majority of calcium current inactivation in frog atrial fibers.
Mentrard et al. (1984) studied this question. Ion substitutions and voltage-clamp was evaluated on Ca current inactivation. Calcium entry mediates most of the calcium current inactivation in frog atrial fibers, with relative inactivation linearly related to the amount of divalent cations carried into the cell.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: