Key result
Ca2+ release-induced ICa inactivation is mediated through local changes of [Ca2+] near Ca2+ channels and ryanodine receptors, evidenced by susceptibility to fast (BAPTA) but not slow (EGTA) buffers.
Population
Single rat ventricular myocytes
Design
Preclinical
Authors
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Local SR Ca²⁺ release drives fast I_Ca inactivation in rat myocytes; extends EC-coupling models but leaves open human translation.
Ca2+ release-induced inactivation of Ca2+ current in rat ventricular myocytes is mediated by local Ca2+ signaling in microdomains near Ca2+ channels and ryanodine receptors.
James S.K. Sham (1997) studied this question. Intracellular dialysis with EGTA or BAPTA was evaluated on Inactivation of Ca2+ current (ICa) induced by Ca2+ release. Ca2+ release-induced ICa inactivation is mediated through local changes of [Ca2+] near Ca2+ channels and ryanodine receptors, evidenced by susceptibility to fast (BAPTA) but not slow (EGTA) buffers.
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