Key result
Neonatal rat atrial K(ATP) channels displayed a conductance of 58.0+/-2.2 pS and a unique pharmacological profile resembling both pancreatic beta-cell and ventricular channel subtypes.
Population
Primary cultured neonatal rat atrial appendage cardiomyocytes
Design
Preclinical
Authors
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Hypothesis-generating in neonatal rat atria; leaves open whether similar channels influence human atrial electrophysiology or therapy.
Neonatal rat atrial appendage cardiomyocytes express a novel heteromultimeric KATP channel with a unique functional and pharmacological profile sharing features of both pancreatic and ventricular subtypes.
Baron et al. (1999) studied Neonatal rat atrial appendage cardiomyocytes. K(ATP) channel openers and inhibitors was evaluated on K(ATP) channel functional and pharmacological properties. Neonatal rat atrial K(ATP) channels displayed a conductance of 58.0+/-2.2 pS and a unique pharmacological profile resembling both pancreatic beta-cell and ventricular channel subtypes.
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