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March 1, 1995Journal of Biological ChemistryOpen Access

Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets, Pituitary, Skeletal Muscle, and Heart

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Population

Rat pancreatic islet cDNA library, Xenopus laevis oocytes, and clonal human kidney epithelial cells (HEK293)

Design

Preclinical

Authors

NINobuya InagakiKitano HospitalYTYoshiyuki TsuuraSuzuka University of Medical ScienceNNNoriyuki NambaTottori University Hospital

Discussion

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Overview

Suggests metabolic-K+ coupling across rat tissues; leaves open its relevance to human cardiovascular physiology or therapy.

Structured PICO

P
Population
Rat pancreatic islet cDNA library, Xenopus laevis oocytes, and clonal human kidney epithelial cells (HEK293)
I
Intervention
Cloning and expression of uKATP-1 cDNA
O
Outcome
Electrophysiological properties and tissue expression of uKATP-1surrogate

The study identifies and characterizes uKATP-1, a novel ubiquitously expressed ATP-sensitive potassium channel that may link cellular metabolic state to membrane K+ permeability.

Cite This Study

Inagaki et al. (1995) studied this question.

synapsesocial.com/papers/6a70dd12e5469ee92be189f3https://doi.org/10.1074/jbc.270.11.5691
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning a novel human brain inward rectifier potassium channel and its functional expression in <i>Xenopus</i> oocytes1994 · 36 citations
  2. 2Atrial G protein-activated K+ channel: expression cloning and molecular properties.1993 · 359 citations
  3. 3Molecular cloning and functional expression of a novel brain‐specific inward rectifier potassium channel1994 · 103 citations
  4. 4Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain.1994 · 117 citations
  5. 5Cloning provides evidence for a family of inward rectifier and G‐protein coupled K<sup>+</sup> channels in the brain1994 · 281 citations