Population
Insulinoma cells and Xenopus oocytes (heterologous expression model)
Design
Preclinical
Authors
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BIR1 alone yields ATP-insensitive currents; leaves open whether native cardiac KATP channels require additional subunits for modulation.
The cloned BIR1 channel shares sequence homology with cardiac KATP channels but lacks ATP sensitivity, suggesting native channels may require heterologous subunits for modulation.
Bond et al. (1995) studied this question.
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