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December 27, 1995FEBS LettersOpen Access

Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle

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Population

Insulinoma cDNA library and HEK293 cells

Design

Preclinical

Authors

HSH SakuraTokyo Women's Medical UniversityCÄCarina ÄmmäläNovo Nordisk (Finland)PSPaul A. SmithEnvironment and Climate Change Canada

Discussion

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Overview

Establishes Kir6.2/SUR as the KATP channel; leaves open its therapeutic targeting in cardiovascular disease.

Structured PICO

P
Population
Insulinoma cDNA library and HEK293 cells
I
Intervention
Cotransfection of Kir6.2 cDNA with sulphonylurea receptor (SUR) cDNA
O
Outcome
Functional expression and electrophysiological properties of the Kir6.2/SUR channel complexsurrogate

The study identifies that the Kir6.2/SUR channel complex constitutes the ATP-sensitive potassium channel.

Cite This Study

Sakura et al. (1995) studied this question.

synapsesocial.com/papers/6a835f3abe60e97fec18fda9https://doi.org/10.1016/0014-5793(95)01369-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cloning and functional expression of the cDNA encoding an inwardly‐rectifying potassium channel expressed in pancreatic β‐cells and in the brain1995 · 46 citations
  2. 2Cloning and Functional Characterization of a Novel ATP-sensitive Potassium Channel Ubiquitously Expressed in Rat Tissues, including Pancreatic Islets, Pituitary, Skeletal Muscle, and Heart1995 · 407 citations
  3. 3Mutations in the Sulfonylurea Receptor Gene in Familial Persistent Hyperinsulinemic Hypoglycemia of Infancy1995 · 818 citations
  4. 4Cloning of the β Cell High-Affinity Sulfonylurea Receptor: a Regulator of Insulin Secretion1995 · 1,330 citations
  5. 5Block of ATP‐regulated and Ca2(+)‐activated K+ channels in mouse pancreatic beta‐cells by external tetraethylammonium and quinine.1990 · 97 citations