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KATP channels are heteromultimeric complexes assembled with a Kir6.0 subfamily K+ channel subunit and a sulfonylurea receptor (SUR) subunit.
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Supports research into KATP-targeted drugs for metabolic and cardiac disorders; leaves open clinical translation from molecular models.
ATP-sensitive K+ channels (KATP channels) play important roles in many cellular functions by coupling cell metabolism to electrical activity. By cloning members of the novel inwardly rectifying K+ channel subfamily Kir6.0 (Kir6.1 and Kir6.2) and the receptors for sulfonylureas (SUR1 and SUR2), researchers have clarified the molecular structure of KATP channels. KATP channels comprise two subunits: a Kir6.0 subfamily subunit, which is a member of the inwardly rectifying K+ channel family; and a SUR subunit, which is a member of the ATP-binding cassette (ABC) protein superfamily. KATP channels are the first example of a heteromultimeric complex assembled with a K+ channel and a receptor that are structurally unrelated to each other. Since 1995, molecular biological and molecular genetic studies of KATP channels have provided insights into the structure-function relationships, molecular regulation, and pathophysiological roles of KATP channels.
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Susumu Seino (1999) reported a review. KATP channels are heteromultimeric complexes assembled with a Kir6.0 subfamily K+ channel subunit and a sulfonylurea receptor (SUR) subunit.
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