Population
In vitro-translated proteins and COS cells transfected with Kir6.2 and SUR1 subunits
Comparison
Coexpression of Kir6.2 and SUR1 vs Expression of Kir6.2 or Kir6.2deltaC37 alone
Design
Preclinical
Authors
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Advances molecular model of cardiac KATP assembly; leaves open therapeutic targeting in human ischemia or arrhythmias.
This study provides direct evidence that the inwardly rectifying K+ channel Kir6.2 and the ATP-binding cassette protein SUR1 physically associate to form functional KATP channels.
Lorenz et al. (1998) studied this question.
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