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August 1, 1999Journal of Biological ChemistryOpen Access

The Molecular Assembly of ATP-sensitive Potassium Channels

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Population

Molecular models studying the interaction between SUR1 and Kir 6.2 subunits of ATP-sensitive potassium…

Design

Preclinical

Authors

JGJonathan P. GiblinConsorci Institut D'Investigacions Biomediques August Pi I SunyerJLJoanne L. LeaneyPfizer (United States)ATAndrew TinkerElectrophysiology

Discussion

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Overview

Clarifies terminal domain roles in KATP channels; leaves open whether modifications can be exploited in channelopathies.

Structured PICO

P
Population
Molecular models studying the interaction between SUR1 and Kir 6.2 subunits of ATP-sensitive potassium channels
I
Intervention
Modifications of the N or C terminus of the channel proteins
O
Outcome
Biochemical and functional manifestations of coupling between SUR1 and Kir 6.2surrogate

The proximal C terminus is necessary but not sufficient for functional communication between SUR1 and Kir 6.2 in ATP-sensitive potassium channels.

Cite This Study

Giblin et al. (1999) studied this question.

synapsesocial.com/papers/6a91312ee32db62f950a24fehttps://doi.org/10.1074/jbc.274.32.22652
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1K <sub>ATP</sub> channel inhibition by ATP requires distinct functional domains of the cytoplasmic C terminus of the pore-forming subunit1998 · 197 citations
  2. 2Cloning and functional expression of the cDNA encoding a novel ATP‐sensitive potassium channel subunit expressed in pancreatic β‐cells, brain, heart and skeletal muscle1995 · 424 citations
  3. 3NAB Domain Is Essential for the Subunit Assembly of both α–α and α–β Complexes of Shaker-like Potassium Channels1996 · 145 citations
  4. 4Novel Subunit Composition of a Renal Epithelial KATPChannel1998 · 92 citations
  5. 5Specification of Subunit Assembly by the Hydrophilic Amino-Terminal Domain of the Shaker Potassium Channel1992 · 460 citations