Key result
Immune system abnormalities are linked to the pathogenesis of insulin resistance in PCOS.
Why the study?
The precise pathogenesis and immunopathogenesis of polycystic ovary syndrome remain unclear, though immune system abnormalities and chronic inflammation are suspected to play a pivotal role in insulin resistance.
Population
Patients with polycystic ovary syndrome
Design
Review
Authors
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May inform immunomodulatory trials in PCOS insulin resistance; leaves open causality and practice change.
This review highlights the complex interplay between immune cells, inflammatory cytokines, and insulin resistance in the pathogenesis of polycystic ovary syndrome.
Zhang et al. (2025) conducted a review in Polycystic ovary syndrome (PCOS) and insulin resistance. Immune system dysregulation was evaluated. Immune system abnormalities, including dysregulated immune cells and inflammatory cytokines, play a pivotal role in the pathogenesis of insulin resistance in patients with polycystic ovary syndrome.
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