Key result
Moderate obesity is associated with impaired resistance arteriolar endothelial function compared to non-obese individuals, an effect that is more prominent in women.
Why the study?
Is moderate obesity associated with impaired conduit and microvascular endothelial function, and are there sex differences?
Cross-Sectional (n=41)
No
Is moderate obesity associated with impaired conduit and microvascular endothelial function, and are there sex differences?
Answers are grounded in this paper and cite their sources.
Moderate obesity is associated with impaired resistance arteriolar endothelial function, particularly in women, and is linked to systemic inflammation.
Our objective was to determine whether moderate obesity (Body Mass Index [BMI] ≥ 30 kg/m²) is associated with impaired conduit and microvascular endothelial function, and whether men or women are more susceptible to impairment of endothelial function related to moderate obesity. Forty-one middle aged, nondiabetic moderately obese (BMI 34.7 ± 4.0 kg/m2) and nonobese (BMI 24.3 ± 2.6 kg/m2) subjects of both sexes underwent noninvasive studies of endothelial function (brachial reactivity) and measurements of endothelial-dependent vasodilation of gluteal subcutaneous arterioles to acetylcholine (Ach). Endothelium-dependent vasodilation to Ach was decreased in the moderately obese compared with the nonobese (P < 0.001). Stratified analysis based on sex showed impairment of arteriolar endothelial function in women BMI ≥ 30 kg/m2 (P = 0.02), but not men. There was no difference between in vivo endothelial function flow-mediated dilation (FMD%) by BMI category. Sex-specific analysis showed FMD% was lower in women with BMI ≥ 30 kg/m2 compared to those with BMI < 30 kg/m2 (P = 0.02). No differences were seen in men based on BMI category (P = 0.18). In women, high sensitivity C-reactive protein (hsCRP) correlated with BMI (ρ = 0.68, P = 0.006). Moderate obesity is associated with impaired resistance arteriolar endothelial function. This is more prominent in women than men and is associated with systemic inflammation.
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Suboc et al. (2013) conducted a cross-sectional in Moderate obesity and endothelial dysfunction (n=41). Moderate obesity (BMI ≥ 30 kg/m²) vs. Non-obese (BMI < 30 kg/m²) was evaluated on Endothelium-dependent vasodilation of gluteal subcutaneous arterioles to acetylcholine (Ach) (p=<0.001). Moderate obesity is associated with impaired resistance arteriolar endothelial function compared to non-obese individuals, an effect that is more prominent in women.
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