Key result
Male gender and higher serum fibrinogen levels were independently associated with worse endothelial function in individuals with excess weight and mild dyslipidemia.
Cross-Sectional (n=74)
No
In individuals with excess weight and mild dyslipidemia, male gender and elevated fibrinogen are independent predictors of endothelial dysfunction as measured by BAFMD.
Answers are grounded in this paper and cite their sources.
Male gender and fibrinogen may mark endothelial dysfunction in excess weight; leaves open causality and clinical utility pending prospective data.
BACKGROUND: Excessive weight is a cardiovascular risk factor since it generates a chronic inflammatory process that aggravates the endothelial function. OBJECTIVE: To evaluate the endothelial function in individuals with excess weight and mild dyslipidemia using brachial artery flow-mediated dilation (BAFMD), and the association of endothelial function with anthropometric and biochemical variables. METHODS: Cross-sectional study that included 74 individuals and evaluated anthropometric variables (body mass index [BMI], waist-hip ratio [WHR], waist circumference [AC], and percentage of body fat [PBF]), biochemical (blood glucose, insulinemia, ultrasensitive C-reactive protein, fibrinogen, total cholesterol, HDL-cholesterol, triglycerides, and LDL-cholesterol) and endothelial function (BAFMD, evaluated by ultrasound). The statistical analysis was performed with SPSS, version 16.0. To study the association between the variables, we used chi-square, Student's t and Mann-Whitney tests, and Pearson's correlation. Logistic regression analyzed the independent influence of the factors. Values of p < 0.05 were considered significant. RESULTS: The participants had a mean age of 50.8 years, and 57% were female. BMI, WC, WHR, and PBF showed no significant association with BAFMD. The male gender (p = 0.02) and higher serum levels of fibrinogen (p = 0.02) were significantly and independently associated with a BAFMD below 8%. CONCLUSIONS: In individuals with excess weight and mild untreated dyslipidemia, male gender and higher levels of fibrinogen were independently associated with worse BAFMD.
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Menti et al. (2016) conducted a cross-sectional in Excess weight and mild dyslipidemia (n=74). Male gender and elevated serum fibrinogen vs. Female gender and lower serum fibrinogen was evaluated on Worse endothelial function defined as brachial artery flow-mediated dilation (BAFMD) < 8% (OR 3.33, 95% CI 1.19-9.28, p=0.02). Male gender and higher serum fibrinogen levels were independently associated with worse endothelial function in individuals with excess weight and mild dyslipidemia.
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