Key result
Carrier detection and fetal diagnosis of Duchenne muscular dystrophy using linked loci can be highly reliable, though precision is limited by recombination fraction estimates and casualty rates.
Population
Duchenne muscular dystrophy
Design
Review
Authors
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Caution advised applying linkage analysis for DMD carrier/fetal testing; leaves open validation against direct sequencing in modern cohorts.
The paper discusses the theoretical limitations and casualty rates associated with carrier detection and fetal diagnosis of Duchenne muscular dystrophy using linked loci.
James Edwards (1986) conducted a review in Duchenne muscular dystrophy. Carrier detection and fetal diagnosis using linked loci was evaluated. Carrier detection and fetal diagnosis of Duchenne muscular dystrophy using linked loci can be highly reliable, though precision is limited by recombination fraction estimates and casualty rates.
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