Key result
Plasma BNP measurement was significantly more accurate than ANP for detecting heart disease in a screening population (AUC 0.94 vs 0.81; p<0.001).
Why the study?
Does measurement of plasma BNP and ANP levels accurately identify patients with heart disease in a multiphasic health screening program?
Cross-Sectional (n=481)
Does measurement of plasma BNP and ANP levels accurately identify patients with heart disease in a multiphasic health screening program?
Absolute Event Rate: 0.94% vs 0.81%
p-value: p=<0.001
Plasma BNP concentration is a highly sensitive and specific biochemical marker for screening asymptomatic patients for various heart diseases in a general population.
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May support BNP for heart disease screening in asymptomatic adults; leaves open prospective outcome validation.
Niinuma et al. (1998) conducted a cross-sectional in Heart disease (n=481). Plasma B-type natriuretic peptide (BNP) measurement vs. Plasma atrial natriuretic peptide (ANP) measurement was evaluated on Identification of patients with heart disease (Area under the ROC curve) (p=<0.001). Plasma BNP measurement was significantly more accurate than ANP for detecting heart disease in a screening population (AUC 0.94 vs 0.81; p<0.001).
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