Key result
Sequencing of poliovirus isolate K/2002 from a vaccinated infant revealed an S3/S2 recombination event and mutations associated with loss of the attenuated Sabin 3 phenotype.
Case Report (n=1)
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The identification of a recombinant Sabin 3/Sabin 2 poliovirus with mutations linked to loss of attenuation highlights the risks of OPV administration and the need for careful vaccination strategies in polio-free regions.
The genetic properties of strain K/2002, isolated from fecal samples of a 7-month-old child who had received his first oral poliovirus vaccine (OPV) dose at the age of 3 months, are described. Preliminary sequencing characterization of isolate K/2002 revealed an S3/S2 recombination event at the 3' end of the VP1 coding region. A recombination event resulted in the introduction of six Sabin 2 amino acid residues in a Sabin 3 genomic background. Furthermore, mutations associated with loss of the attenuated phenotype of Sabin 3 strains have been identified in the genome of isolate K/2002. The data presented here emphasize the need for careful planning of vaccination strategies, which involve stopping OPV administration in regions that are certified to be polio-free.
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Dedepsidis et al. (2008) conducted a case report in Vaccine-derived poliovirus (n=1). Oral poliovirus vaccine (OPV) was evaluated on Genetic properties and sequencing characterization of isolate K/2002. Sequencing of poliovirus isolate K/2002 from a vaccinated infant revealed an S3/S2 recombination event and mutations associated with loss of the attenuated Sabin 3 phenotype.
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